Trimethyl orthoformate, with the chemical formula (CH3O)3CH, is an organic compound commonly used as a reagent in organic synthesis. It appears as a colorless liquid with a pungent odor.
Applications:
Acylation Reactions: Trimethyl orthoformate is used as a reagent in acylation reactions to introduce formyl groups into organic compounds.
Protecting Group: It serves as a protecting group for alcohols in organic synthesis, preventing unwanted reactions at the hydroxyl group.
Methylation Reactions: It is employed in methylation reactions, where it serves as a source of methyl groups.
Intermediate: Trimethyl orthoformate is utilized as an intermediate in the pharmaceutical and agrochemical industries for the synthesis of various compounds.
| Property | Specification |
|---|---|
| Chemical Formula | (CH3O)3CH |
| Molecular Weight | 118.13 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | 102-103°C |
| Melting Point | -109°C |
| Density | 0.946 g/cm3 at 20°C |
| Solubility | Miscible with most organic solvents |